Porous Starch: a Novel Carrier for Solubility Enhancement of Carbamazepine
نویسندگان
چکیده
منابع مشابه
Development of modified porous starch as a carrier to improve aqueous solubility
The objective of this work was to improve aqueous solubility of poorly water soluble drugs by a modified porous starch as solid dispersion carrier. The yield of the porous starch was found to be 80%. The flow property of the prepared porous starch was found to be good, with good compressibility index. The particle size of the prepared porous starch were found to be in the range of 53–130μ. Ther...
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متن کاملDevelopment of Microemulsion for Solubility Enhancement of Clopidogrel
Clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. Oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. The aim of this investigation was ...
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Objective: Solubility is a key parameter as it is one of the main causes for poor bioavailability. The objective was to improve the solubility and dissolution profile of poorly-soluble silymarin with a water-soluble carrier fulvic acid. Materials and methods: Phase solubility studies were carried out for the determination of stoichiometric ratio between silymarin and fulvic acid by Higuchi and ...
متن کاملdevelopment of microemulsion for solubility enhancement of clopidogrel
clopidogrel, an inhibitor of platelet aggregation, selectively inhibits the binding of adenosine diphosphate (adp) to its platelet receptor and the subsequent adp-mediated activation of the glycoprotein gpiib/iiia complex, thereby inhibiting platelet aggregation. oral bioavailability of clopidogrel is very low (less than 50%), due to its poor water solubility. the aim of this investigation was ...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2013
ISSN: 1530-9932
DOI: 10.1208/s12249-013-9985-6